Kyriakos Chatziikyriakidis studied History at the School of History and Archaeology of the Aristotle University of Thessaloniki, where he received a PhD in Modern and Contemporary History. During the academic years 2009-2010 and 2010-2011 he was a Visiting Lecturer at the Department of History and Archaeology of the Cyprus State University. Since 2017, he is Assistant Professor of the Chair of Pontic Studies at the School of History and Archaeology, Faculty of Philosophy, Aristotle University of Thessaloniki. During the academic year 2019-2020, he taught and supervised postgraduate theses in the Postgraduate Program on Black Sea Hellenism, School of Humanities, Social and Economic Sciences, International University of Greece. Since 2020 Kyriakos Chatzikyriakidis has been teaching at the Hellenic Open University (Hellenic Open University) as an Associate Faculty member.

His research interests, his presentations in Greek and international conferences and his books are related to topics of Modern Greek History: Economic and Social History of Hellenism in the East (Anatolia) and Cyprus (19th-early 20th century), The Greek Diaspora, The Greek Revolution of 1821, The Refugee Issue in Greece (1900-1940).