Emeritus Professor, Dr. Konstantinos Litinas,

Laboratory of Organic Chemistry, Chemistry Department,

 Aristotle University of Thessaloniki, Thessaloniki, Greece.

e-Mail: klitinas@chem.auth.gr

Year/Place of Birth: May 1955/ Rethymnon, Crete, Greece.

Family Status: Married, with a daughter and a son.

Undergraduate studies: 1973-1978, Chemistry Department, School of Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece. Bachelor, in Chemistry (March 1978).

Postgraduate studies: 1978-1984, Laboratory of Organic Chemistry, Chemistry Department, School of Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece (under the supervision of Prof. D. N. Nicolaides). “Studies on reactions of o-quinones with phosphonium ylides” (PhD. Grade Excellent, May 1984).

Postdoctoral studies: 1992-1993, California Institute of Technology, Caltech, Pasadena, California, USA (Research in Olefin Metathesis, under the supervision of Prof. R. H. Grubbs, Nobel Laureate in Chemistry, 2005).

Fellowships: 1978-1981, Fellowship from National Fellowship Foundation (I.K.Y.) for PhD studies in Greece.

Academic Career: Laboratory of Organic Chemistry, Chemistry Department, School of Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece:

1981-1986: Scientific Fellow.

1986-1991: Lecturer.

1991-1999: Assistant Professor.

1999-2013: Associate Professor.

2013-2022: Professor

2023, April: Emeritus Professor

Military service: 1984-1986.

Research areas:

• Οrganic Synthesis.
• Natural Products Synthesis.
• Synthesis of compounds with possible biological activity.

• Synthesis of modified N-homonucleosides

• Application of organometallic reagents in Organic Synthesis
• Applications of metal-nanoparticles in Organic Synthesis

Research Funding:

• PYTHAGORAS II, 2005 “Synthesis of new pyrano[2,3-h]chromen-6-ones (pyranocoumarins) and 4-aza-analogues and study of their biological activity”.
• HERAKLEITUS II, 2010: “Synthesis and study of pyranoquinolinones (pyrido­cou­ma­rins) and fused derivatives of them with possible biological interest” (PhD Symeonidis);
• HERAKLEITUS II, 2010: “Synthesis of homonucleosides and heterocyclic derivatives of purines with possible biological interest” (PhD Thalassitis);
• HERAKLEITUS II, 2010: “Synthesis and study of pyranoindolones (pyrrolocoumarins) and fused derivatives of them with possible biological interest” (PhD Vronteli).

• Operational Programme “Human Resources Development, Education and Lifelong Learning” Partnership Agreement (PA) 2014-2020, 2020: “Synthesis of fused pyranoquinolinone derivatives with possible biological interest”

Publications in Book Chapters:

Contribution with other colleagues in Experimental Organic Chemistry, A. General Part, Gartaganis Publishing., Thessaloniki, Greece, 2009 and in Experimental Organic Chemistry, B. Specific Part, Gartaganis Publishing., Thessaloniki, Greece, 2010.

Contribution with other colleagues to the translation of Klein Organic Chemistry, Utopia Publishing, Athens, Greece, 2015.

Contribution with other colleagues to the translation of Pavia, Lampman, Kriz, VyVyan Introduction to Spectroscopy, Broken Hill, Nicosia, Cyprus, 2020.

Contribution with other colleagues to the translation of Pavia, Lampman, Kriz, Engel A Microscale Approach to Organic Chemistry Laboratory Techniques, Broken Hill, Nicosia, Cyprus, 2020.

Publications in peer-reviewed Journals: 96.

Presentations in Scientific Congress: 98

Selected Publications:

– M. D. Douka, I. M. Sigala, E. Nikolakaki, K. C. Prousis, D. J. Hadjipavlou-Litina, K. E. Litinas, ChemistrySelect 2024, 9, e202401957. Cu-Catalyzed Synthesis of Coumarin-1,2,3-Triazole Hybrids connected with Quinoline or Pyridine Framework.

– E.-E. N. Vlachou, E. Pontiki, D. J. Hadjipavlou-Litina, K. E. Litinas, Organics 2023, 4, 364. Synthesis and Biological Evaluation of Substituted Fused Dipyranoquinolinones.

– C. Christou, I. Pavlou, I. Sigala, E. Nikolakaki, D. J. Hadjipavlou-Litina, K. E.  Litinas, Arkivoc 2023 (vii) 202312085. Synthesis of pyridocoumarin β-glycosides with possible biological activity.

– M. Douka, K. E. Litinas. Molecules 2022, 27, 7256.An Overview on the Synthesis of Fused Pyridocoumarins with Biological Interest.

– E.-E. N. Vlachou, I. Fotopoulos, C. Gabriel, E. Pontiki, D. J. Hadjipavlou-Litina, K. E. Litinas. Eur. J. Med. Chem. Reports 2022, 5, 100063. Synthesis and biological evaluation of fused dipyranoquinolinones as inhibitors of acetylcholinesterase with antioxidant properties.

– T. D. Balalas, M. G. Kanelli, C. Gabriel, E. Pontiki, D. J. Hadjipavlou-Litina, K. E. Litinas. Synthesis 2022, 54, 2894. Pd Catalyzed N-H or C-H functionalization/oxidative cyclization for the efficient synthesis of N-aryl substituted [3,4]-fused pyrrolocoumarins.

– M. D. Douka, K. E. Litinas. Arkivoc, 2021, (viii), 107-118.One-pot synthesis of 5H-chromeno[3,4-b]pyrazin-5-one derivatives from 4-amino-3-nitrocoumarin and α-dicarbonyl compounds.

– T. D. Balalas, A. K. Theologis, K. Mazaraki, C. Gabriel, E. Pontiki, D. J. Hadjipavlou-Litina, K. E. Litinas Arkivoc 2020, vi, 126. Efficient synthesis of 2-substituted 1-phenylchromen[3,4-d]imidazol-4(1H)-ones with possible anti-inflammatory activity.

– Vlachou, E.-E.; Gabriel, C. Litinas, K. E. J. Heterocyclic Chem.2019, 56, 99.

One-pot Synthesis of Fused Dipyranocoumarins from Dihydroxycoumarins and Propargyl Chlorides under Microwave Irradiation

– T. D. Balalas, G. Stratidis, D. Papatheodorou, E.-E. Vlachou, C. Gabriel, D. J. Hadjipavlou-Litina, K. E. Litinas SynOpen 2018, 2, 105. One-pot Synthesis of 2-Substituted 4H-Chromeno[3,4-d]oxazol-4-ones from 4-Hydroxy-3-nitrocoumarin and Acids in the Presence of Triphenylphosphine and Phosphorus Pentoxide under Microwave Irradiation.

– E.-E. N. Vlachou, G. S. Armatas, K. E. Litinas J. Heterocyclic Chem. 2017, 54, 2447. Synthesis of fused oxazolocoumarins from o-hydroxynitrocoumarins and benzyl alcohol under gold nanoparticles or FeCl₃ catalysis

– T. Balalas, A. Abdul-Sada, D. J. Hadjipavlou-Litina, K. E. Litinas Synthesis 2017, 49, 2575. Pd-Catalyzed efficient synthesis of azacoumestans via intramolecular cross coupling of 4-arylaminocoumarins in the presence of copper acetate under microwaves.

– T. Balalas, C. Peperidou, D. J. Hadjipavlou-Litina, K. E. Litinas Synthesis 2016, 48, 281. Phenyliodine(III) Bis(trifluoroacetate) Mediated Synthesis of 6-Piperidinylpurine Homo-N-nucleosides Modified with Isoxazolines or Isoxazoles.

–  A. Vronteli, D. J. Hadjipavlou-Litina, M. Konstantinidou, K. E. Litinas ARKIVOC 2015, iii, 111. Synthesis of fused pyranocarbazolones with biological interest.

– A. N. Thalassitis, D. J. Hadjipavlou-Litina, K. E. Litinas J. Heterocyclic Chem., 2015, 52, 366. Synthesis of Fused 9,10-Dihydro-6H-Azepino- and 9,10-Dihydro-6H-[1,3]Diazepino[1,2-e]Purines via Ring Closing Metathesis as Antilipid Peroxidation Agents.

– M. G Kallitsakis, M. Yaρez, E. Soriano, J. Marco-Contelles, D. J Hadjipavlou-Litina, K. E Litinas, Future Medicinal Chemistry 2015, FMC 7, 103. Purine homo-N-nucleoside+coumarin hybrids as pleiotropic agents for the potential treatment of Alzheimer’s disease.

– M. G. Kallitsakis, D. J. Hadjipavlou-Litina, A. Peperidou, K. E. Litinas. Tetrahedron Lett. 2014, 55, 650. Synthesis of 4-hydroxy-3-[(E)-2-(6-substituted-9H-purin-9-yl)vinyl]coumarins as lipoxygenase inhibitors.

– T. S. Symeonidis, K. E. Litinas. Tetrahedron Lett. 2013, 54, 6517. Synthesis of methyl substituted [5,6]- and [7,8]-fused pyridocoumarins via the iodine-catalyzed reaction of aminocoumarins with n-butyl vinyl ether.

– T. S. Symeonidis, I. N. Lykakis, K. E. Litinas. Tetrahedron, 2013, 69, 4612. Synthesis of quinolines and fused pyridocoumarins from N-propargylanilines or propargylaminocoumarins by catalysis with gold nanoparticles supported on TiO₂

– M. G. Kallitsakis, D. J. Hadjipavlou-Litina, K. E. Litinas. J. Enz. Inh. Med. Chem. 2013, 28, 765. Synthesis of purine homo-N-nucleosides modified with coumarins as free radical scavengers.